Lisinopril: dose‐peak effect relationship in essential hypertension.

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Abstract
1. The dose‐peak effect relationship of lisinopril was evaluated in a double‐blind, parallel study in 83 patients with mild to moderate essential hypertension (supine diastolic blood pressure = 95‐115 mm Hg). 2. After a 4 week placebo washout, patients were randomly assigned to one of four treatments: lisinopril 2.5, 10, 20 or 80 mg day‐1 for 1 week. 3. Lisinopril 10 and 20 mg day‐1 produced similar peak antihypertensive effects which were greater than that produced by 2.5 mg day‐1, but less than that of 80 mg day‐1. If the incidence of first‐ dose symptomatic hypotension is related to the peak effect, then an initial lisinopril dose of 20 mg should not pose any greater risk than a 10 mg dose. 4. The magnitude of antihypertensive response at 24 h postdrug appeared to be dose related across the 2.5 to 80 mg day‐1 range.