Effect of denervation on fluid flow into rat mammary gland

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Abstract
The resistance to fluid flow into the mammary gland of the anesthetized rat was measured by recording the time taken for 0.1 ml fluid to enter the gland under a constant-pressure head (90 mm Hg). Denervation of the gland caused a marked decrease in the resistance to the entry of citrated milk but had no effect on the compliance characteristics of the glands. This effect of denervation was mimicked by the intraductal injection of lignocaine. The effect of denervation on fluid flow was not observed if the rat had been pretreated with the sympatholytic drug phenoxybenzamine or if 2% lignocaine was used instead of milk to fill the mammary gland; in these animals resistance to fluid flow was very low both before and after denervation. It is concluded that, in the rat, there is active regulation of mammary ductal tone perhaps involving the sympathetic nervous system.

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