EFFECT OF RANITIDINE ON INTRINSIC-FACTOR SECRETION AND COBALAMIN ABSORPTION
- 1 January 1983
- journal article
- research article
- Vol. 7 (4) , 381-384
Abstract
The effects of ranitidine, a new potent histamine H2-receptor antagonist, on gastric intrinsic factor (IF) secretion and protein-bound cobalamin absorption were evaluated in 6 patients with duodenal ulcer, before, during and after discontinuation of ranitidine therapy. Oral ranitidine (150 mg twice a day) resulted in a nonsignificant decrease of IF concentration and IF output, but was responsible for malabsorption of protein-bound cobalamin. This malabsorption was reversible upon discontinuation of ranitidine. Occurrence of cobalamin deficiency cannot be excluded during long-term ranitidine treatment and the need for careful follow-up in these patients is emphasized.This publication has 9 references indexed in Scilit:
- Cimetidine and malabsorption of cobalaminDigestive Diseases and Sciences, 1982
- Effect of Cimetidine on the Absorption of Vitamin B12Scandinavian Journal of Gastroenterology, 1982
- Vitamin B12 Absorption from FishExperimental Biology and Medicine, 1981
- Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer.Gut, 1981
- Histamine H2Receptors and Intrinsic Factor SecretionScandinavian Journal of Gastroenterology, 1980
- Malabsorption of protein-bound cobalamin but not unbound cobalamin during cimetidine administrationDigestive Diseases and Sciences, 1980
- Clinically significant vitamin B12 deficiency secondary to malabsorption of protein-bound vitamin B12Digestive Diseases and Sciences, 1979
- Rapid Charcoal Assay for Intrinsic Factor (IF), Gastric Juice Unsaturated B12 Binding Capacity, Antibody to IF, and Serum Unsaturated B12 Binding CapacityBlood, 1965
- INTRINSIC FACTOR STUDIES .2. THE EFFECT OF GASTRIC JUICE ON THE URINARY EXCRETION OF RADIOACTIVITY AFTER THE ORAL ADMINISTRATION OF RADIOACTIVE VITAMIN-B121953