Cytotoxic Quassinoids from Simaba cedron
- 5 May 1998
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (6) , 776-780
- https://doi.org/10.1021/np980023f
Abstract
Four new quassinoids, cedronolactones A−D (1−4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1−4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 μg/mL) against P-388 cells.Keywords
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