Selective cleavage of tert-butyldimethylsilyl ethers with neutral alumina

1 January 1992

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 19,p. 1451-1453
https://doi.org/10.1039/c39920001451

Abstract

Neutral alumina, partially deactivated with 1.5–3% water, is an efficient and selective agent for cleavage of tert-butyldimethylsilyl ethers in the presence of other acid-sensitive protective groups for alcohols.

Keywords

CLEAVAGE
ETHERS
TERT
BUTYLDIMETHYLSILYL
DEACTIVATED
ALCOHOLS
EFFICIENT
PARTIALLY
NEUTRAL
ALUMINA