We present here a study of the lipoid content of the various tissues of the body in a case of Schüller-Christian's disease together with a review and discussion of the literature to date. Because of the severe anemia encountered in this case we include a parallel study on the tissue of a child of about the same age with similar anemia due to another cause. It was our idea that the latter might in a way act as a control. It has been our hope that should a case of accident come to autopsy we could present our own normal figures. This opportunity has not presented itself. METHODS The material was obtained from the autopsy table as soon as possible. All extraneous blood and tissue were carefully removed. None of the tissue was perfused. It was ground in a meat grinder and weighed. It was then placed in 95 per