AUGMENTATION OF THE CONCENTRATION OF ANGIOTENSINE CONVERSION ENZYME-1 IN THE ALVEOLAR FLUID OF SUBJECTS SUFFERING FROM SARCOIDOSIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 35  (5) , 170-171
Abstract
Angiotensin-converting enzyme (ACE) was assayed in serum (SACE) and in bronchoalveolar fluid lavage (LACE) in 14 healthy controls and 45 patients with sarcoidosis with mediastinal and pulmonary involvement. Concentration of SACE was 4466 .+-. 2202 U .cntdot. 100 ml-1 (.hivin.x [mean] .+-. SD) in sarcoidosis and 2470 .+-. 547 in controls. Concentrations of LACE were 65.2 .+-. 48.4 and 21.1 .+-. 14.7 U .cntdot. 100 ml-1, respectively, in sarcoidosis and controls. These results suggest an intraalveolar secretion of ACE in sarcoidosis. LACE could be a better criterion than SACE for the evaluation of the pulmonary activity of sarcoidosis.