Cytological and immunological examination of cerebrospinal fluid in 9 patients with ramsay hunt's syndrome.

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Abstract
Immunological and cytological examination was made of CSF in 9 patients with Ramsay Hunt''s syndrome. Among the serum immunoglobulins, IgG in 1 and IgM in 5 of 9 cases increased. The Varicella zoster antibody titer was significantly elevated in sera of all 9 cases and in CSF of all 7 examined cases. There was positive fluorecence to Varicella zoster virus in 2 of 4 cases in which CSF smears were examined. The cells showing fluorescence were 10.5% in the former and 1.5% in the latter. Pleocytosis was found in all cases, and CSF cell count ranged from 52-2000/3 mm3 in the early stage. In 3 cases, immunoglobulin-containing cells (IgG and IgM) were seen .apprx. 2-20% within 2 wk of onset. IgG contents increased in all cases; IgG% increased in 8 of 9 cases; IgA concentration increased in 7 cases; and IgA% increased in 7 of 9 cases. Varicella zoster virus apparently spreads to the meninges and CSF from ganglions in patients with Ramsay Hunt''s syndrome.

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