Delayed allograft rejection by T cell receptor Vβ8.1 transgenic mice peripherally tolerized to Mls‐1

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Abstract
One commonly studied model system for peripheral tolerance is the antigen‐specific unresponsiveness of T cells from mice previously inoculated with superantigens such as Mls‐1a. In this study, we used a TcR Vβ8.1 transgenic mouse model to investigate whether mice peripherally tolerized to Mls‐1a exhibit delayed skin allograft rejection. We report dramatic prolongation of skin allograft survival in Vβ8.1 transgenic but not in non‐transgenic mice tolerized to Mls‐1a. Peripherally induced unresponsiveness to Mls‐1a can, therefore, be considered true tolerance.