IgM Deposition in Skin Biopsies from Patients with Primary Biliary Cirrhosis
- 12 January 1981
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 210 (1-6) , 317-320
- https://doi.org/10.1111/j.0954-6820.1981.tb09823.x
Abstract
Immunofluorescence studies on skin biopsies from 14 patients with primary biliary cirrhosis (PBC) showed granular papillary deposition of IgM in all. In addition, 6 patients had C3 deposition. Control patients with various other liver diseases, idiopathic high plasma levels of IgM and extrahepatic cholestasis were only sporadically positive for IgM and not at all for C3. IgM deposition in dermal papillae in PBC does not merely reflect high plasma IgM levels or cholestasis but probably represents an immunochemically abnormal IgM population.Keywords
This publication has 17 references indexed in Scilit:
- An association between primary biliary cirrhosis and jejunal villous atrophy resembling celiac diseaseDigestive Diseases and Sciences, 1979
- Circulating Immune Complexes and Complement Activation in Primary Biliary CirrhosisNew England Journal of Medicine, 1978
- PRIMARY BILIARY CIRRHOSIS AND CŒLIAC DISEASEThe Lancet, 1978
- CŒLIAC DISEASE: A CAUSE OF VARIOUS ASSOCIATED DISEASES?The Lancet, 1975
- Mitochondrial antibodies (AMA).Gut, 1974
- BILE CANALICULAR ANTIBODY IN PRIMARY BILIARY CIRRHOSIS AND IN OTHER LIVER DISEASESThe Lancet, 1973
- Asymptomatic primary biliary cirrhosisGut, 1973
- Preservation of Tissue-Fixed Immunoglobulins in Skin Biopsies of Patients with Lupus Erythematosus and Bullous DISEASES—Preliminary ReportJournal of Investigative Dermatology, 1972
- Immunoglobulins in chronic liver disease.Gut, 1968
- SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSISThe Lancet, 1965