Inhibition of Frusemide-Induced Natriuresis by Indomethacin in Patients with the Nephrotic Syndrome
- 1 February 1977
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 52 (2) , 149-151
- https://doi.org/10.1042/cs0520149
Abstract
1. In four patients with nephrotic syndrome indomethacin not only reduced proteinuria but also inhibited the natriuretic effect of high doses of frusemide. 2. The inhibition of natriuresis by indomethacin could not be antagonized by albumin infusions. 3. Only the combined use of spironolactone and frusemide induced a natriuresis during indomethacin treatment. Spironolactone alone was ineffective. 4. It is suggested that inhibition of prostaglandin synthesis by indomethacin, in the presence of a stimulated renin-angiotensin system and hyperaldosteronism, may cause this strong tendency to sodium retention.Keywords
This publication has 2 references indexed in Scilit:
- Diuretic Properties of Furosemide in Renal DiseaseAnnals of Internal Medicine, 1968
- Redistribution of Renal Blood Flow Produced by Furosemide and Ethacrynic AcidCirculation Research, 1967