Influence of Hyper and Hypothyroidism on Susceptibility of Mice to Infection with Lansing Poliomyelitis Virus.

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Abstract
Young mice were made hyperthyroid by feeding iodinated casein or hypothyroid by feeding 6-n-propyl-2-thiouracil. After receiving these substances in the diet for 7-11 days they were inoculated intracerebrally with a brain-cord suspension of Lansing poliomyelitis virus. In one series hypothyroidism seemed to favor a higher incidence of paralysis, but this could not be substantiated in 2 other series. The only consistent deviation from the normal course of infection was an increased incidence of deaths without signs of paralysis in hyperthyroid mice. The hyperthyroid condition may either (1) favor the proliferation of virus (2) cause death by imposing an additional burden on the already taxed metabolism.