Possible Role of ATP in Dimerization of Myosin Molecules from Chicken Gizzard Muscle1

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Abstract
The mechanism of ATP hydrolysis by chicken gizzard myosin was investigated at 0.2 M KCl where dimerization of myosin occurs as well as at 0.3 M KCl where dimerization of myosin does not occur. We also found that upon addition of AMPPNP, a dimeric form of gizzard myosin was produced in 0.2 M KCl. Therefore, ATP hydrolysis appears not to be required for the formation of myosin dimers.