Plasma Concentration and Biosynthesis of Testosterone in the Syndrome of Feminizing Testes1

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Abstract
The concentration of plasma testosterone was found to be within the range for normal adult men in 3 typical instances of the feminizing testes syndrome. Gonadectomy resulted in a sharp decrease in plasma values of testosterone, although the lowest level reached was still somewhat above the range for castrated men and normal females. Evidence was obtained showing that the adrenal cortex contributed, in part, to the circulating level of testosterone. In vitro biosynthesis of testicular tissue showed it capable of synthesizing testosterone from progesterone and androstenedione and estrogens from testosterone and androstenedione. A phenolic steroid metabolite was also obtained from the latter 2 substrates which closely resembled the chromatographic characteristics of equilenin.

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