Primary structure and biological activity of hemoglobin-related hypothalamic peptides
- 1 January 1997
- journal article
- review article
- Published by Wiley in Biopolymers
- Vol. 43 (2) , 135-137
- https://doi.org/10.1002/(sici)1097-0282(1997)43:2<135::aid-bip6>3.0.co;2-w
Abstract
Five individual fractions from bovine hypothalamic extract, displaying coronary constrictory activity, were isolated and sequenced. All of them belong to the hemorphin group of hemoglobin-derived peptides. These peptides bind calmodulin and activate calmodulin-dependent enzymes. The relationship of isolated peptides with other members of the hemorphin group is discussed. Several new fragments of hemoglobin alpha- and beta-chains with yet unidentified activity were obtained from the same source. Their amino acid sequences have considerable overlap with the known sequences of hemoglobin fragments isolated from other tissues.Keywords
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