Attempt at Experimental Production of Carcinoma in Gastric Ulcer

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Abstract
For experimental demonstration of malignant change of gastric ulcer, a beeswax pellet containing 5 mg of 4-nitroquinoline-l -oxide and 2 mg of histamine phosphate was inserted in an artificial pouch of the glandular stomach of rats. Of the 14 rats autopsied after 153-336 days, 11 animals exhibited a chronic penetrating ulcer at the site of pellet application. In 5 of these 11 rats, some epithelial cells of the regenerating mucosa at the margin of the ulcer were quite atypical and infiltrated deeply into scar tissues of the ulcer base in a pattern suggestive of malignancy. In another rat, a tumor of the size of a finger tip occupied the margin and a part of the ulcer base, which was histologically mucoid adenocarcinoma. Although these results do not present a conclusive evidence of malignant change of gastric ulcer, this method of investigation is expected to provide a very effective means for further studies on the relationship between ulceration and carcinogenesis in the stomach.

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