Studies on Ganoderma lucidum. IV. Effects on the Disseminated Intravascular Coagulation

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Abstract
Effects of the aqueous extract of G. lucidum, collected in Kyoto (K) and Odawara (O) [Japan], on experimentally disseminated intravascular coagulation (DIC) in rats was investigated. K prevented the decrease of blood platelet and fibrinogen, the prolognation of prothrombin time and the increase of fibrin degradation products (FDP) at a dose of 500 mg/kg in normal rats on DIC induced by endotoxin. O prevented the decrease of blood platelets at a dose of 500 mg/kg. K and O prevented the formation of hepatic vein thrombosis induced by endotoxin in hyperlipemic rats. In order to reveal the mode of in vivo action of K and O, the activities of K and O for blood platelet aggregation, thrombin action and fibrinolytic action were examined in vitro. K and O showed inhibitory effects on blood platelet aggregation induced by collagen, and on thrombin action at concentrations of 500-1000 .mu.g/ml.

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