Experimental Comparison of EOE-13 and Perfluoroctylbromide for the CT Detection of Hepatic Metastases

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Abstract
The relative advantages of EOE-13 [ethiodized oil emulsion 13] and perfluoroctylbromide (PFOB) as contrast agents were evaluated using CT [computed tomography] scanning in animals [rabbits] with implanted liver tumors. Three criteria were used to compare these compounds: the density difference between liver and tumor, the presence of opacification of intrahepatic vascular structures and the presence of ring enhancement around the tumors. All 3 radiographic features were superior in the scans after injection of 5 g/kg of PFOB. When a reduced dose (1.7 g/kg) of PFOB was used, however, the scans obtained with EOE-13 were of approximately equal quality. If toxicity problems prevent administration of PFOB in humans, then EOE-13 will probably remain the contrast agent of choice for tumor imaging in the liver.