Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium
Top Cited Papers
- 22 January 2010
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5964) , 466-469
- https://doi.org/10.1126/science.1179663
Abstract
Garnering Information on Granulomas: In tuberculosis, the tuberculous granuloma has been viewed traditionally as a host-protective structure that serves to “wall off” mycobacteria. However, recent work in the zebrafish embryo showed that mycobacteria convert the nascent granuloma into a vehicle for bacterial expansion and dissemination. Thus, intercepting granuloma formation could provide a strategy for treating tuberculosis, an urgent public health goal in light of the epidemic of extensively drug-resistant tuberculosis. Now Volkman et al. (p. 466 , published online 10 December; see the Perspective by Agarwal and Bishai ) present the molecular pathway by which mycobacteria induce granulomas in zebrafish. Inhibition of this pathway attenuates infection by reducing granuloma formation, suggesting a therapeutic target for tuberculosis treatment.This publication has 31 references indexed in Scilit:
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