Therapy of the Hypereosinophilic Syndrome

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Abstract
Previous studies of patients with the hypereosinophilic syndrome found very significant morbidity and a high mortality of 77% at 3 yr. The therapy and prognosis of 26 patients with the hypereosinophilic syndrome were analyzed. Five patients showed no evidence of progressive organ-system dysfunction and were given no therapy, all have done well. Sixteen patients with progressive organ dysfunction were treated with corticosteroids. Six of the 16 had a good response and needed no further therapy. Five patients were treated with various chemotherapeutic agents that were ineffective. In 8 patients who were unresponsive to corticosteroid therapy, hydroxyurea produced excellent responses in 6 and partial responses in 2. With the above regimen, 26 patients (including 12 with poor prognostic indicators) have had a marked increase in survival (3 yr mortality of 4%) when compared with the historical control group.

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