Effect of Cohn Fractionation Conditions on Infectivity of the AIDS Virus

Publisher Website
Google Scholar
Abstract
To the Editor: Intravenous gamma globulins prepared by means of Cohn fractionation have been reported to transmit non-A, non-B hepatitis viruses,1 2 3 suggesting that the alcohol concentration, pH, and temperature used in this process do not completely inactivate these lipid-membrane–coated viruses. Since the virus causing AIDS (human T-cell lymphotropic virus Type III [HTLV-III], lymphadenopathy-associated virus, or AIDS-related virus), hereafter called the AIDS virus, may be present in plasma pools used for manufacturing blood derivatives,4 5 6 it is important to determine whether the virus can survive the fractionation procedure.We therefore performed the following experiment. Plasma from a small number of donors shown . . .