Formation of a Pharmacologically Active Substance from Plasma Protein.
- 1 January 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 100 (1) , 100-102
- https://doi.org/10.3181/00379727-100-24537
Abstract
Evidence has been presented on the formation of a pharmacologically active substance from fraction IV-4 of plasma protein by the action of an alpha-amylase preparation. Formation of the active substance stimulates the isolated guinea pig ileum and produces a pressor response on dog and rabbit blood pressure. It differs from bradykinin since that substance is a vasodilator. The active substance produced by the action of alpha-amylase on fraction IV-4 of plasma protein has been provisionally designated as substance A.Keywords
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