CIRCULATORY EFFECTS OF ORAL AND SUBCUTANEOUS ADMINISTRATION IN NORMAL SUBJECTS OF A NEW BRONCHODILATOR, IBUTEROL, A PRO‐DRUG TO TERBUTALINE
Open Access
- 1 September 1976
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 58 (1) , 43-46
- https://doi.org/10.1111/j.1476-5381.1976.tb07691.x
Abstract
1 The di‐isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitatively different. 2 By mouth, ibuterol acted more rapidly, and was 2–3 times more active. After intramuscular injection, ibuterol caused less increase in local blood flow than terbutaline. 3 Ibuterol can be regarded as a pro‐drug, which in itself has little activity, but which can be made active in the body.Keywords
This publication has 7 references indexed in Scilit:
- Comparison between ibuterol hydrochloride and terbutaline in asthma.BMJ, 1976
- Pharmacological Properties of 1‐(3′5′‐diisobutyryloxy‐phenyl)‐2‐(t‐butylamino)‐ethanolhydrochloride (KWD 2058), a New Sympathomimetic BronchodilatorActa Pharmacologica et Toxicologica, 1974
- Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths).1971
- Resistance to β‐adrenoceptor stimulants (a possible explanation for the rise in asthma deaths)British Journal of Pharmacology, 1971
- CIRCULATORY EFFECTS OF ORCIPRENALINE, ADRENALINE AND A NEW SYMPATHOMIMETIC β‐RECEPTOR‐STIMULATING AGENT, TERBUTALINE, IN NORMAL HUMAN SUBJECTSActa Medica Scandinavica, 1970
- Measurement of Muscle Blood-Flow With133Xe After Histamine Injection As A Diagnostic Method in Peripheral Arterial DiseaseScandinavian Journal of Clinical and Laboratory Investigation, 1965