Serum Gonadotropin Patterns in Patients with Chronic Renal Failure on Hemodialysis

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Abstract
A clinical model to study gonadotropin patterns when minimal or no kidney function persists is available in patients demonstrating chronic renal failure and maintained on hemodialysis. Hemodialysis does not alter the serum level of FSH and LH. In 9 premenopausal women, 3 serum patterns of FSH and LH were observed. The most common serum pattern of gonadotropin is a normal concentration of FSH and a moderately elevated level of LH, wherein LH/FSH is 4:1. This pattern was also observed in 4 male patients maintained on hemodialysis. The serum gonadotropin pattern in oophorectomized women on hemodialysis is the same as in post-menopausal women with normal renal function (i.e. high LH and high FSH). Serum estrogen levels are below normal in all female patients studied. Renal failure does not induce a suppression in the hypothalamic-pituitary control of gonadotropin release. Renal failure is not associated with an unique serum pattern of FSH and LH. This suggests that kidney excretion is not the only mechanism for clearing gonadotropin from blood.

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