Value of a Single Night-Time Dose of Potassium Clorazepate in Anxiety: A Controlled Trial Comparison with Diazepam

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Abstract
A total of 29 patients with anxiety or anxiety/hysteria, participated in a double-blind, cross-over trial of two benzodiazepine anxiolytics, diazepam and potassium clorazepate. The problems of a ‘carry-over’ effect and a possible order of drug administration effect are discussed in relation to analysis of results. Clorazepate proved the more effective drug, as shown by a reduction in total symptom scale of Kellner Symptom Rating Test and the reduction in sub-scales for anxiety, depression, somatic complaints and general neurotic symptoms with parallel symptom reduction in linear analogue scales. Side effects were infrequent with both drugs and posed no clinical problem. Potasium clorazepate in a single nightly dose of 15 mg proved to be more effective than thrice daily (5mg) diazepam.

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