Cerebral glucose is detectable by localized proton NMR spectroscopy in normal rat brain in Vivo

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Abstract
This contribution reports the first direct and noninvasive observation of cerebral glucose in normal anesthetized rats (n = 16) using short-echo-time localized proton NMR spectroscopy (2.35 T, STEAM, TR = 6000 ms, TE = 20 ms, 125 μl). In addition to resonances from N-acetyl aspartate (NAA), glutamate, total creatine, cholines, taurine, and myo-inositol, all spectra exhibit strongly coupled resonances from glucose (3.43, 3.80 ppm) that are readily identifiable using model solutions. The observed level of cerebral glucose in fasted rats covered a range of 15–4096 of that of NAA giving absolute concentrations of 1.1–2.8 mM when NAA is taken to be 7 mM. The arterial blood glucose concentration was 7.7 ± 0.8 mM in the same group Of animals.