β‐2‐microglobulin in benign and malignant adnexal skin tumors and metastasizing basocellular carcinomas

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Abstract
Immunostaining for .beta.-2-microglobulin (.beta.-2m) was performed on various benign and malignant adnexal [human] skin tumors and 3 cases of metastasizing basocellular carcinomas. All the tumors and their metastases, with the exception of 2 basocellular carcinomas gave evidence of .beta.-2m. Most tumors contained both stained and unstained cells. The stained cells showed differentiation, the unstained ones appeared to be undifferentiated and basallike in character. The staining of cutaneous tumors for .beta.-2m may offer a tool for investigating tumor differentiation, but seems not to be of much value in distinguishing malignant from benign lesions.