Kainic acid-induced lesion of dopaminergic target cells in the striatum: Consequences on the dynamics of cerebellar cGMP
- 1 August 1978
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 304 (1) , 5-7
- https://doi.org/10.1007/bf00501370
Abstract
The bilateral intrastriatal injection of kainic acid (2 μg/caudate) caused a marked decrease in the activity of striatal dopamine-sensitive adenylate cyclase. This probable loss of target cells for dopamine was associated with a parallel decrease of the cGMP level in the cerebellar cortex, which was maximal (80% loss) by 24 h and prevented apomorphine from raising cerebellar cGMP levels. On the contrary harmaline and isoniazid both increased the levels of cerebellar cGMP in kainic-lesioned rats to the same extent as in control rats. The results indicate that dopamine mechanisms in the striatum are involved in the regulation of cerebellar cortex cGMP.This publication has 16 references indexed in Scilit:
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