TISSUE PROTEIN STUDIES IN NORMAL AND UNDERNOURISHED MALES: THE CHANGES IN TOTAL CIRCULATING PROTEIN AFTER AN INTRAVENOUS SALINE INFUSION AS AN INDEX OF PROTEIN STORES 1

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Abstract
A relatively shbrt and rapid method of demonstrating the presence or absence of labile protein stores in man is presented. Plasma volume, total circulating proteins, and fractions (albumin and globulin) were determined before and after an intraven. infusion of 1 liter of physiological saline in 6 normal and in 9 undernourished subjects. The response to the saline infusion demonstrated by the normal subjects was characterized by an increase in plasma volume, an avg. of 440.7 ml., and an increase in total circulating protein, an avg. of 13.9 g. The response to the saline infusion demonstrated by the undernourished subjects was characterized by an increase in plasma volume, an avg. of 169.9 ml., and a decrease in total circulating protein, an avg. of 14.7 g.
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