DIFFERENTIAL REACTIVITY OF ALPHA-FETOPROTEIN WITH LECTINS AND EVALUATION OF ITS USEFULNESS IN THE DIAGNOSIS OF HEPATOCELLULAR-CARCINOMA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 75  (9) , 809-815
Abstract
The reactivity of .alpha.-fetoprotein(AFP) with concanavalin A (Con A) and Lens culinaris agglutinin (LCA) was studied by crossed immuno-affinoelectrophoresis of the serum samples of 146 patients from 3 groups (groups I, II and III). Patients (51) with benign liver diseases were included in group I, 83 patients with hepatocellular carcinoma in group II, and 12 patients with carcinoma metastatic to the liver from digestive organs in group III. In group I, the percentage of Con A-reactive species of AFP was high (97 .+-. 5%, mean .+-. SD), but that of LCA-reactive species was verly low (3 .+-. 5%). The percentage of LCA-reactive species of AFP in group II (45 .+-. 33%) was higher than that in group I (P < 0.001), while the Con A binding pattern of AFP in this group, as demonstrated by immuno-affinoelectrophoresis, was similar to that of group I. The percentage of Con A-reactive species of AFP in grou III (55 .+-. 24%) was much lower than that in group II (97 .+-. 5%) (P < 0.001). Measurement of the reactivity of AFP in serum samples with Con A and LCA may be useful for the differentiation of AFP species which are found in association with benign liver diseases, hepatocellular carcinoma and carcinoma metastatic to the liver.

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