Distribution and Properties of Lysosomal Enzymes in Untreated and in Irradiated Mouse Mammary-Gland Carcinomas2

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Abstract
The subcellular distribution of various lysosomal hydrolases was investigated in C3H mammary carcinomas before and after X irradiation, and the results were correlated with electron-histochemical findings. Homogenates from irradiated tumors showed an increase of total activities and a shift from sedimentable toward unsedimentable activities. These biochemical changes were accompanied by an increase in the number and size of lysosomes in tumor cells and a moderate infiltration of phagocytic elements. Cytochemically, the tumor cells revealed an enhancement of activity of the Golgi elements and a development of primary lysosomes as well as dense bodies and autophagic vacuoles. The observed behavior is compatible with the idea that an intracellular shift of hydrolases toward areas of cytoplasmic degradation is related to the injurious attack by ionizing radiation.

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