Abstract
In discussing the care of neuropathic ulcers, Caputo et al. (Sept. 29 issue)1 claim that “topical iodine preparations, astringents, and hydrogen peroxide interfere with the healing of the wound,” and they cite two references to support this statement.2,3 The first reference reported not that these topical agents interfered with wound healing but rather that povidone–iodine and saline were less effective than silver sulfadiazine in reducing bacterial counts in chronic pressure ulcers.2 Many other studies have documented the broad antimicrobial effectiveness of povidone–iodine. A controlled clinical study that we sponsored showed that wounds treated with povidone–iodine cream had 100 percent reepithelialization in a significantly shorter period (12.1 days, P4 Several other controlled clinical studies have shown wound healing to be enhanced, rather than harmed, by treatment with povidone–iodine cream.5