Defensins: antimicrobial peptides of innate immunity
Top Cited Papers
- 1 September 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (9) , 710-720
- https://doi.org/10.1038/nri1180
Abstract
The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.Keywords
This publication has 169 references indexed in Scilit:
- Genetic Variants of Human β-Defensin-1 and Chronic Obstructive Pulmonary DiseaseBiochemical and Biophysical Research Communications, 2002
- Inhibition of hBD-3, but Not hBD-1 and hBD-2, mRNA Expression by CorticosteroidsBiochemical and Biophysical Research Communications, 2001
- hBD‐1: a novel β‐defensin from human plasmaPublished by Wiley ,2000
- Molecular cloning and tissue expression of porcine β‐defensin‐1FEBS Letters, 1998
- Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domainFEBS Letters, 1995
- Gallinacins: cysteine‐rich antimicrobial peptides of chicken leukocytesFEBS Letters, 1994
- Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesinsFEBS Letters, 1993
- Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowelFEBS Letters, 1993
- Solution structures of the rabbit neutrophil defensin NP-5Journal of Molecular Biology, 1988
- The corticostatic (anti-ACTH) and cytotoxic activity of peptides isolated from fetal, adult and tumor-bearing lungJournal of Steroid Biochemistry, 1987