Protective effect of erythropoietin in neonatal hypoxic ischemia in mice
- 1 September 2003
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 14 (13) , 1757-1761
- https://doi.org/10.1097/00001756-200309150-00020
Abstract
The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.Keywords
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