Neurotoxicity assessment of O-ethyl-O'-(2-diisopropylaminoethyl) methylphosphonite (QL) in hens

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Abstract
O‐ethyl‐O'‐(2‐diisopropylaminoethyl) methylphosphonite (QL), an intermediate in the formation of ethyl S‐2‐diisopropylaminoethyl methylphosphonothiolate, was evaluated for neurotoxicity in the adult hen. Birds were given a single oral dose of QL ranging from 635 to 6080 mg kg−1. The QL‐treated hens were observed for up to 24 h after dosing for acute toxicologic effects and over a 24 d post‐dose period for evaluation of delayed neurotoxicity. The oral LD50 in hens is 1186 mg kg−1. Neurologic dysfunction, as evidenced by motor incapacitation, was observed at 6 days and thereafter after treatment with QL. Neurotoxic esterase (NTE) activity was not inhibited at 24 h after exposure to compound. Neural damage, multifocal in nature, was noted in the peripheral nervous system of QL‐treated hens at dose levels ≥ 635 mg kg−1, oral dose. These findings indicate neural damage tendencies following QL exposure.