Haemodynamic changes resulting from thrombin induced intravascular coagulation

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Abstract
Thrombin induced intravascular coagulation in dogs resulted in systemic hypotension due to fall in total peripheral vascular resistance as the cardiac output was unchanged. An increase in pulmonary vascular resistance occurred when thrombin was infused into the right atrium or pulmonary artery. These early haemodynamic changes are thought to be due to a release of vasoactivity rather than occlusion of the microcirculation by thrombin or cell aggregation.