Pharmacokinetics of the Antidepressant Rolipram in Healthy Volunteers
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 19 (6) , 683-692
- https://doi.org/10.3109/00498258909042306
Abstract
1. The pharmacokinetics of rolipram were studied in healthy male volunteers using 3H-rolipram and a radioimmunoassay for measurement of unchanged drug. 2. Rolipram was rapidly and completely absorbed after an oral dose of 1 mg. Bioavailability was 73%. 3. Plasma levels of the unchanged drug declined with a terminal half-life of 2h. The total clearance of rolipram was 2 ml/miin per kg. 4. Labelled rolipram was excreted rapidly and completely. The main route of elimination was via the urine.This publication has 7 references indexed in Scilit:
- Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differencesXenobiotica, 1988
- Results of a Phase II Study of the Antidepressant Effect of RolipramPharmacopsychiatry, 1984
- Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitorsNeuropharmacology, 1983
- Characteristic behavioral alterations in rats induced by rolipram and other selective adenosine cyclic 3?,5?-monophosphate phosphodiesterase inhibitorsPsychopharmacology, 1982
- The Influence of Rolipram on the Central Serotoninergic SystemPharmacopsychiatry, 1981
- A program library for computing the parameters of linear compartment models in pharmacokineticsInternational Journal of Bio-Medical Computing, 1980
- Pharmacokinetics of the β-Adrenergic Blocker Sotalol in DogsJournal of Pharmaceutical Sciences, 1973