Enamel Pitting

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Abstract
Dental enamel pitting as a diagnostic sign of tuberous sclerosis (TSC) is explored and a protocol for the oral examination of patients and individuals at risk is described. In the study, 50 patients with TSC and 250 control patients were examined for dental enamel pitting. A simple clinical protocol was established for examination using a dental disclosing solution swabbed on dry teeth. The incidence of enamel pitting in the adult dentition of patients with TSC was 100%, whereas that in the adult dentition of the control group was 7%. The simplicity of the test and the high probability of occurrence in TSC make it an important tool in the diagnosis of this serious genetic disease.