A Pneumotropic Line of Lymphocytic Leukemia from Inbred Princeton Mice

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Abstract
Lymphocytic leukemia, of sporadic occurrence in random-bred Princeton mice (3.1% in 1050 adults), was transmitted to weanlings by intraperitoneal injection of lymphoid organ suspensions and maintained by serial passage. Spleens and regional lymph nodes were commonly enlarged but lungs were not involved. A high level leukemia line from inbred Princeton mice, originally established by Dr. Clara Lynch, was similarly maintained in random-bred weanlings. Neoplastic cells also proliferated in lymphoid tissue, though with evidence of increased toxicity, and also invaded the lungs. Pulmonary lesions as well as generalized ones were regularly produced by intranasal injection of cells from high leukemia line but not from the low level one. Necrotic lesions of liver appeared in one passage series with each of the 2 lines and murine hepatitis viruses of low virulence were recovered.