DOSE-DEPENDENT SULFOCONJUGATION OF SALICYLAMIDE IN DOGS - EFFECT OF SULFATE DEPLETION OR ADMINISTRATION

  • 1 January 1985
    • journal article
    • research article
    • Vol. 234  (2) , 431-434
Abstract
The effects of plasma inorganic sulfate concentrations on the dose-dependent kinetics of salicylamide (SAM) were examined in the dog. Decreasing plasma sulfate concentrations from 0.9 mM to < 0.3 mM significantly decreased clearance of a small dose of SAM (5 mg/kg) to the sulfate conjugate. Infusing sodium sulfate to prevent the decrease in plasma inorganic sulfate concentration that follows an oral 20-mg/kg dose of SAM did not increase SAM elimination. However, sodium sulfate given orally decreased SAM bioavailability, which suggests a local effect of sulfate on intestinal 1st-pass metabolism of SAM. These data show some dependence of SAM metabolism on plasma inorganic sulfate concentrations, but only when they are markedly reduced.

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