Trichloroisocyanuric/TEMPO Oxidation of Alcohols under Mild Conditions: A Close Investigation
- 13 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (12) , 4999-5001
- https://doi.org/10.1021/jo034276b
Abstract
Efficient oxidation of primary alcohols to the corresponding carboxylic acids can be carried out at room temperature and in acetone/water, using trichloroisocyanuric acid (TCCA) in the presence of catalytic TEMPO. The mild conditions of this procedure and the total absence of any transition metal make this reaction suitable for safe laboratory use. A possible mechanism is presented and discussed.Keywords
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