Effect of crystallinity on the percutaneous absorption of corticosteroid. I. Determination of the degree of crystallinity of hydrocortisone acetate in ground mixtures with crystalline cellulose.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (2) , 795-801
- https://doi.org/10.1248/cpb.33.795
Abstract
The effect of the crystallinity of a topically applied drug on its percutaneous absorption was investigated with hydrocortisone acetate as a model drug. To decrease the degree of crystallinity, the drug was ground with crystalline cellulose. The X-ray diffraction method for determining the degree of crystallinity was valid in the range of amorphous cellulose ratio of 0 to .apprx. 50% by using simple mixtures of glutathione and amorphous cellulose. The dissolution rate of hydrocortisone acetate was confirmed to increase quantitatively with decreasing cystallinity.This publication has 2 references indexed in Scilit:
- Sarin Transport across excised Human Skin II: Effect of Solvent Pretreatment on PermeabilityJournal of Pharmaceutical Sciences, 1979
- Dissolution behaviors and gastrointestinal absorption of phenytoin in phenytoin-polyvinylpyrrolidone coprecipitate.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978