Homeobox genes and development of the vertebrate CNS
- 5 February 1989
- Vol. 10 (2-3) , 82-85
- https://doi.org/10.1002/bies.950100211
Abstract
The discovery of homeobox genes in vertebrates may allow analysis of a basic problem in developmental neurobiology: how regional differences in CNS organization are specified during development. This view is based on the roles defined for homologous genes in Drosophila development, and is supported by studies of the patterns of homeobox gene expression in vertebrate embryos. Homeobox genes comprise a multigene family, members of which are expressed in different spatially restricted domains along the anterior‐posterior axis of the CNS. These observations are consistent with homeobox genes having roles in the positional specification of CNS organization, and experimental tests of this should be forthcoming shortly.Keywords
This publication has 37 references indexed in Scilit:
- Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouseNature, 1989
- Segmental patterns of neuronal development in the chick hindbrainNature, 1989
- A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotypeCell, 1988
- The pituitary-specific transcription factor GHF-1 is a homeobox-containing proteinCell, 1988
- The molecular genetics of embryonic pattern formation in DrosophilaNature, 1988
- Expression of homeo box genes during mouse development: a review.Genes & Development, 1988
- The segmentation and homeotic gene network in early Drosophila developmentCell, 1987
- Sequence analysis of the murine Hox-2.2, −2.3, and −2.4 homeo boxes: Evolutionary and structural comparisonsGenomics, 1987
- The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene winglessCell, 1987
- Nomenclature for homoeobox-containing genesNature, 1987