EFFECT OF CORONARY BLOOD-FLOW ON UPTAKE AND WASHOUT OF TC-99M DMPE AND TL-201

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (12) , 1102-1110
Abstract
After i.v. administration of 99mTc DMPE [dichlorobis(1,2-dimethylphosphine)ethane] the flow-dependent kinetics were studied in dogs during induced ischemia and during induced maximal reactive hyperemia. A control group was also studied. Mean time-activity curves obtained from the myocardial wall were compared within the same intervention group and also with other groups. During reactive hyperemia, there was a rapid and absolute increase in uptake followed by a rapid washout, whereas during ischemia there was a slow and decreased uptake followed by a slow washout. The magnitude of 99mTc DMPE uptake during reactive hyperemia was slightly less than that of 201Tl, but the decreased uptake with ischemia was about equal for the 2 agents. Following maximal uptake in the myocardium the effective half-life of 99mTc DMPE was 1/3-1/4 that of 201Tl. The similar kinetics of 99mTc DMPE compared to 201Tl suggests its usefulness in the evaluation of ischemic heart disease.

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