Dissociation of duodenogastric marker reflux and bile salt reflux

Publisher Website
Google Scholar
Abstract
Duodenogastric reflux of a perfused marker and bile salt reflux, as well as emptying of fasting gastric contents and gastric secretion, were measured simultaneously in six healthy volunteers. Each of the subjects was studied three times in randomized order during intravenous administration of either saline or atropine (40 μg/kg/4 hr) or cerulein (360 ng/kg/4 hr). Fractional gastric emptying rate was inhibited from 4.57 %/min±0.50se to 0.70±0.15 by atropine (PPPP<0.05). It is concluded that reflux of duodenal contents and reflux of bile salts do not necessarily parallel each other. This may produce considerable confusion by apparently contradictory results in studies on duodenogastric reflux.