The hydrolysis of estramustine phosphate; in vitro studies
- 1 October 1983
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 8 (4) , 395-402
- https://doi.org/10.1007/bf03188772
Abstract
The ester bond by which nornitrogen mustard is linked to estradiol-17-phosphate was slowly cleaved by enzymes from the liver and prostate of the rat, dog and man. The dog tissues were more effective than those of the rat and man. Intestinal enzy-mes also exhibited the ability to hydrolyze the carbamic ester, but to a greater extent in the rat than in the dog. It is concluded that, with regard to the metabolism of estramustine, the rat is more similar to man than is the dog. Possible clinical implications of the biotransformation of estramustine phosphate are discussed.This publication has 29 references indexed in Scilit:
- Pharmacokinetics of estramustine phosphate (Estracyt®) in prostatic cancer patientsEuropean Journal of Clinical Pharmacology, 1984
- 17α and 17β-oxidoreductases of adult female hamster liver and kidneyJournal of Steroid Biochemistry, 1982
- Chloroethylnitrosourea Cancer Chemotherapeutic AgentsPublished by Elsevier ,1982
- Metabolism of estramustine phosphate (Estracyt ®) in patients with prostatic carcinomaEuropean Journal of Drug Metabolism and Pharmacokinetics, 1981
- Studies on a Nitrogen Mustard of Estradiol in Dogs and RatsExperimental Biology and Medicine, 1977
- Estramustine Phosphate Therapy in Carcinoma of the ProstatePublished by Springer Nature ,1977
- Treatment of Advanced Prostatic Carcinoma with Estramustine Phosphate (Estracyt®)Scandinavian Journal of Urology and Nephrology, 1977
- 19 Acid PhosphatasesPublished by Elsevier ,1971
- Treatment of Advanced Prostatic Carcinoma with Estracyt: A Preliminary ReportScandinavian Journal of Urology and Nephrology, 1971
- Carbamate ester latentiation of physiologically active aminesJournal of Medicinal Chemistry, 1970