THE EFFECTS OF SODIUM SALICYLATE ON THE OXYGEN CONSUMPTION OF RATS

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Abstract
The effects of sodium salicylate on oxygen consumption of intact rats and rats treated with tubocurarine have been studied. Intraperitoneal injections of sodium salicylate in untreated rats produced varying results which depended on both the dose and the concentration used. Intravenous injections in rats treated with curare gave rise to an increase in oxygen consumption which was proportional to the log dose over a range of 0.0625 mg./g. to 0.5 mg./g. body weight. It was concluded that sodium salicylate stimulated the oxygen consumption of rats when the concentration of the drug in the plasma was high.