Some Early Nuclear Effects of Ionizing Radiation.

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Abstract
Frozen-dried, dry-mounted, Feulgen-stained prepns. of irradiated rat and mouse tissues were employed to study early cytologic changes after ionizing radiation. Fine nuclear details were preserved by the freezing-drying method. Lethal radiation effects observed in radiosensitive cells included formation of large intranuclear vacuoles with stretching of nuclear membranes. Nonlethal changes in radioresistant tissues comprised smaller intranuclear vacuoles, decreased Feulgen stain of nuclear chromatin and sap, and loss of regular sharp staining of nuclear membranes. Such changes in liver cells may contribute to acute radiation syndrome. Histochemical technics may provide a better understanding of tissue changes after ionizing radiation.

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