The Synthesis of an Exhaustively Stereodiversified Library of cis-1,5 Enediols by Silyl-Tethered Ring-Closing Metathesis
- 14 June 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (14) , 2157-2159
- https://doi.org/10.1021/ol0159569
Abstract
This report describes the parallel synthesis of all 16 stereoisomers of the cis-1,5 enediol module 1. Compounds 1 derive from 2 by silicon-tethered ring-closing metathesis. Such libraries of stereodiversified ligands provide a unique approach to ligand discovery that employs exhaustive searching of conformational space.Keywords
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