Analogues of luteinizing hormone-releasing hormone with modification in position 3.

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Abstract
Six analogues of LH-RH [luteinizing hormone-releasing hormone] in which the tryptophan residue in position 3 was replaced by nonprotein amino acids, were synthesized and evaluated for their LH-RH activity. The analogues substituted by amino acids having the fused aromatic ring structure in the side-chain retained relatively high biological activity. The potency of [3-(1-naphthyl)-L-alanine]3-LH-RH was 187.1% of that of synthetic LH-RH. The fused aromatic ring structure of the side-chain in position 3 is a favorable factor, and that the indolyl NH group in the TRP residue is not essential.

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